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The Program
When to Apply
Advisement
Transfer Policy
Courses
Medicinal Chemistry - B.S.
Medicinal Chemistry - B.S./M.S.
Medicinal Chemistry - Minor
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Medicinal Chemistry
Department of Chemistry
College of Arts and Sciences
363 Natural Sciences Building
North Campus
Buffalo, NY 14260-3000
(716) 645-6800 ext. 2035
Fax: (716) 645-6963
Web: Chemistry
Jim D. Atwood, Chair
James W. McIver Jr., Director of Undergraduate Studies
The bachelor of science degree program in medicinal chemistry is designed to provide (1) a basic chemical understanding of life processes and biological control; (2) a chemical basis for the rational design, synthesis, and mechanism of action of drugs, and selective metabolic inhibition; (3) the basic laboratory skills necessary for research in medicinal chemistry; (4) an appreciation of medicinal chemistry and the chemical aspects of pharmacology; and (5) a chemically oriented foundation for postbaccalaureate research and study in medicinal chemistry and professional studies in the health sciences.
Depending upon the choice of electives, this program can provide an optimum background for employment as a B.S.-level medicinal chemist in research institutes, industry, and government; for entrance to graduate school in this or related areas; and for entrance to medical school.
During the middle of the sophomore year, applicants should bring a copy of their current UB DARS report directly to the Department of Chemistry.
Students may be referred to Dr. James McIver, the director of undergraduate studies, for advisement regarding the prerequisite courses and any other aspect of the program and discipline. Students are advised to meet with him at least once every semester to discuss career goals and curriculum. A student's academic progress is evaluated at the end of each semester.
Prerequisite courses taken by students at other institutions are generally accepted as equivalent to University at Buffalo courses that have comparable titles (e.g., general chemistry, organic chemistry, calculus, etc.).
300 Herbs and Phytomedicinals (3) (Sp)
Sources, identification of active drugs when known, plant parts used, medicinal use, pharmacological basis of action when known, preparations used, dosage recommendations, and adverse effects and contraindications of herbs used for medicinal purposes. LEC
311 The Chemistry of Drug Action (3) (F)
Prerequisite: CHE201-202 or equivalent; intended audience-pharmacy majors
Intended for pharmacy majors. Physicochemical and structural basis of drug action; drug sources; mechanisms of drug action; drug design and selectivity; drug incompatibility; drug interactions. LEC
401 Molecular Structure and Reaction Mechanisms in Medicinal Chemistry (4) (F)
Prerequisites: CHE201-202, CHE319
Principles of structural, physical, and physical-organic chemistry; mechanistic considerations involved in synthetic organic chemistry, bioorganic chemistry, and design for chemotherapeutic agents. LEC
403 Mechanisms of Drug Action (3) (Sp)
Prerequisites: CHE201-202, BCH403, PGY300, recommended
Within specific drug classes of pharmacodynamic and chemotherapeutic drugs, drug structures, and structure-activity relationships, mechanisms of action, and other factors that influence drug action. LEC
408 Undergraduate Research Participation in Medicinal Chemistry (1-6) (F; Sp)
Prerequisites: CHE201-202, CHE322 or CHE413
Projects in medicinal chemistry involving a literature search and lab work. LAB
427 Combinatorial Chemistry (2/1) (F)
Prerequisites: CHE202-202 or CHE251-252, or permission of instructor
Focuses largely on the medicinal and synthetic organic chemistry aspects of the design, simultaneous synthesis and computerized tracking of many new compounds in a highly efficient and automated fashion. Students may take the lecture module alone, but the lab requires completion of the lecture and permission of the instructor. LAB/LEC
499 Independent Studies (var) (F; Sp)
Prerequisite: CHE201-202
Development of a special topic of student interest under a tutorial arrangement. TUT
Minimum GPA of 2.0 overall
BCH403 Principles of Biochemistry
BIO200 Evolutionary Biology
BIO201 Cell Biology
CHE101 General Chemistry or CHE105 Chemistry: Principles and Applications
CHE102 General Chemistry or CHE106 Chemistry: Principles and Applications
CHE201 Organic Chemistry or CHE251 Contemporary Organic Chemistry
CHE202 Organic Chemistry or CHE252 Contemporary Organic Chemistry
CHE319 Physical Chemistry
MCH401 Molecular Structure and Reaction Mechanisms in Medicinal Chemistry
MCH402 Principles of Synthetic Organic Chemistry or CHE455 Advanced Organic Chemistry
MCH403 Mechanisms of Drug Action
MCH408 Undergraduate Research Participation in Medicinal Chemistry*
MCH412 Instrumental Analysis
MTH141 College Calculus I
MTH142 College Calculus II
PHY107 General Physics I
PHY108 General Physics II
PHY158 General Physics II Lab
15 credits of science electives (approximately 5 courses)
See Baccalaureate Degree Requirements (page 254) for general education and remaining university requirements.
First Year
Fall-CHE101 or CHE105, MTH141, BIO200
Spring-CHE102 or CHE106, MTH142, BIO201
Second Year
Fall-CHE201 or CHE251, PHY107
Spring-CHE202 or CHE252, PHY108, PHY158
Third Year
Fall-CHE319, BCH403, one science elective
Spring-MCH402 or CHE455, two science electives
Fourth Year
Fall-MCH401, MCH412, one science elective
Spring-MCH408*, MCH403, one science elective (if necessary)
*Four credits of research is the required minimum for the medicinal chemistry B.S. degree. It is most advantageous for students to complete the research requirement in one semester; however, if additional research is completed, it will be counted towards the 15 credit hours required in science electives. A student may complete the research requirement in the spring semester of the junior year, or either semester of the senior year.
Students must see the graduate secretary (645-6800, ext. 2030) of the Department of Chemistry for admission to the program.
BCH403 Principles of Biochemistry
BIO200 Evolutionary Biology
BIO201 Cell Biology
CHE101 General Chemistry or CHE105 Chemistry: Principles and Applications
CHE102 General Chemistry or CHE106 Chemistry: Principles and Applications
CHE201 Organic Chemistry or CHE251 Contemporary Organic Chemistry
CHE202 Organic Chemistry or CHE252 Contemporary Organic Chemistry
CHE349 Physical Chemistry for Life Sciences
CHE350 Physical Chemistry for Life Sciences Laboratory
CHE412 The Chemistry of Biological Systems
CHE413 Instrumental Analysis
CHE455 Synthetic Organic Chemistry
CHE502 Synthetic Organic Chemistry
MCH408 Undergraduate Research Participation in Medicinal Chemistry*
MCH501 Medicinal Chemistry
MCH524 Mechanisms of Drug Action
MCH615-616 Graduate Research
MCH622 Seminar
MCH700 Thesis Guidance
MTH141 College Calculus I
MTH142 College Calculus II
PHY107 General Physics I
PHY108 General Physics II
PHY158 General Physics II Lab
10 credits of science electives
See Baccalaureate Degree Requirements (page 254) for general education and remaining university requirements.
First Year
Fall-CHE101 or CHE105, MTH141, BIO200
Spring-CHE102 or CHE106, MTH142, BIO201
Second Year
Fall-CHE201 or CHE251, PHY107, one science elective
Spring-CHE202 or CHE252, PHY108/158, two science electives
Third Year
Fall-BCH403, CHE349, CHE350
Spring-CHE455, MCH408, one science elective
Fourth Year
Fall-CHE413, MCH501, MCH408, graduate science elective
Spring-CHE502, MCH524, graduate science electives
Fifth Year
Fall-MCH615, MCH622, graduate science elective
Spring-MCH616, MCH700, graduate science elective
Refer to the Graduate School's Policies and Procedures Manual for Master's candidate requirements.
Minimum GPA of 2.0 overall
Minimum GPA of 2.0 in CHE201-202
CHE201-202 Organic Chemistry
MCH311 The Chemistry of Drug Action
MCH403 Mechanisms of Drug Action
CHE413 Instrumental Analysis or CHE322 Inorganic Chemistry II
BCH403 Principles of Biochemistry or CHE412 Chemistry of Biological Systems
Questions and Comments about this site should be sent to:
- Academic Affairs
- Phone: (716) 645-6003
- Fax: (716) 645-2549
Last updated: Thursday, 09-Dec-2004 15:21:18 EST
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